| Acronym | Definition |
|---|
| HSC | Center for Studying Health System Change |
| HSC | Higher School Certificate (school exit exam; NSW, Australia) |
| HSC | Health Sciences Center |
| HSC | High School Confidential |
| HSC | Health and Social Care (course) |
| HSC | Home Safety Council |
| HSC | Health Services Corporation |
| HSC | Herve Schauer Consultants (France) |
| HSC | Hot Spring County (Arkansas) |
| HSC | Health System Change |
| HSC | Health and Safety Commission (United Kingdom) |
| HSC | Hematopoietic Stem Cell |
| HSC | Hampden-Sydney College (Virginia) |
| HSC | High Speed Cutting |
| HSC | High Speed Communication (various companies) |
| HSC | Health Service Commission |
| HSC | Healthcare Supply Chain (various organizations) |
| HSC | High Speed Craft |
| HSC | Hospital for Sick Children (Toronto, Canada) |
| HSC | Health Services Conference (various locations) |
| HSC | Holy Spirit College (Atlanta, GA) |
| HSC | Hamburger Segel-Club (German yachting association) |
| HSC | Heat Shock Cognate |
| HSC | Human Services Council (various locations) |
| HSC | Help and Support Center (Microsoft) |
| HSC | High Speed Catamaran (watercraft) |
| HSC | Horizontal Split-Case (centrifugal pump) |
| HSC | Help and Support Center |
| HSC | Hybrid Sports Concept |
| HSC | High Speed Controller |
| HSC | High Security Core |
| HSC | Head State Change |
| HSC | Hierarchical Storage Controller |
| HSC | High Speed Connection |
| HSC | Highway Smart Card |
| HSC | Heat Sink Case |
| HSC | High Speed Chip |
| HSC | High Speed Counter |
| HSC | High Speed Centronic |
| HSC | High Speed Cable |
| HSC | Hardware/Software Codesign (various organizations) |
| HSC | Homeland Security Committee (various organizations) |
| HSC | Hard Shell Case |
| HSC | Housing Service Center (U.S. Navy) |
| HSC | Hornsby Shire Council (Australia) |
| HSC | Homeland Security Council (US government) |
| HSC | High School Certificate |
| HSC | High-Strength Concrete |
| HSC | Home Study Course |
| HSC | Hillfield-Strathallan College (Hamilton, Canada) |
| HSC | HomeSchool Association of California |
| HSC | High Sulfur Content (fuel) |
| HSC | Hindu Students Council |
| HSC | Hysteroscopy |
| HSC | High Sierra Camp (Sierra Nevada mountains) |
| HSC | Honda of South Carolina (Timmonsville, SC) |
| HSC | Hemlock Semiconductor Corporation (Hemlock, MI) |
| HSC | Huntington Society of Canada |
| HSC | Hierarchical Storage Controller (computing) |
| HSC | Humane Society of Canada |
| HSC | Hentai Social Club (gaming site) |
| HSC | Health Services Command (US Army) |
| HSC | Honda Sports Concept |
| HSC | Human Services Committee |
| HSC | High Speed Channel |
| HSC | High-Speed Chase |
| HSC | Headquarters Support Company |
| HSC | Half Slotted Container (corrugated box style) |
| HSC | Home Shopping Club |
| HSC | Highway Safety Commission (various locations) |
| HSC | Healthy School Communities (Association for Supervision and Curriculum Development) |
| HSC | Housing Scrutiny Committee (UK) |
| HSC | Hot Swap Controller |
| HSC | Helicopter Combat Support Squadron |
| HSC | Hughes Space and Communications Company (Los Angeles, California) |
| HSC | Human Systems Center (US Air Force) |
| HSC | House Science Committee (US Congress) |
| HSC | Health Services Cluster (various locations) |
| HSC | Harmonised System Committee (World Customs Organization) |
| HSC | Host Software Component |
| HSC | Hungarian Society of Cinematographers |
| HSC | High School Consortium |
| HSC | Hardware/Software Coordination |
| HSC | Huntsville Simulation Conference |
| HSC | Ho Chi Minh City Securities Corporation (Vietnam) |
| HSC | Headquarters Service Company (Army specific) |
| HSC | Hartford Soccer Club (various locations) |
| HSC | High Speed Converter |
| HSC | Human Services Coalition of Dade County |
| HSC | Hope Scholarship Credit |
| HSC | Huntsville Soccer Club (Huntsville, AL) |
| HSC | Home Station Check |
| HSC | Hughes Systique Corporation (Rockville, MD) |
| HSC | Hospitality Sign Company (now hotelsigns.com) |
| HSC | Hardware Systems Command |
| HSC | Hierarchical Structure Code |
| HSC | Hazardous Substances Committee (OSPAR Commission) |
| HSC | Home School Committee (UK) |
| HSC | United States Army Health Services Command |
| HSC | Hydraulic System Controller |
| HSC | Hillsdale Shopping Center (California) |
| HSC | Head Strategic Command |
| HSC | Huntsville Soaring Club (Alabama, aviation) |
| HSC | Health Strategies Consultancy |
| HSC | Hayes Specialties Corp (Saginaw, Michigan) |
| HSC | Hyper-Spherical Coordinate |
| HSC | Hand and Shoe Contamination |
| HSC | Harmonic Stripline Cavity |
| HSC | High Speed Conferencing |
| HSC | Hamlet Swim Club |
| HSC | Harwell Subroutine Library (Aspen) |
| HSC | Handset Control |
| HSC | Home and School Council |
| HSC | Hierarchical Spectral Clustering |
| HSC | High Speed Compactor |
| HSC | Harmonic System Commodity (standardized product identification system) |
| HSC | Hydrophone Signal Conditioner |