The SAM complex consists of dCas9-VP64 complex, sgRNA with two MS2 RNA aptamers, and MS2 RNA-binding protein (MCP) fused to activators p65 and
HSF1. (e) Fusion of dcas9 with KRAB repressor can be used to achieve transcriptional repression.
Voellmy, "Repression of heat shock transcription factor
HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with
HSF1," Cell, vol.
Increases in
HSF1 translocation and synthesis in human epidermoid A-431 cells, role of protein kinase C and [[Ca.sup.2+]].
(2014) Heat shock transcription factor
HSF1 regulates the expression of the Huntingtin-interacting protein HYPK.
Lead author Kazue Hasimoto-Torii, PhD, Principal Investigator of the Center for Neuroscience, Children's National Health System, and a Scott-Gentle Foundation investigator and his team found that mouse embryos exposed to alcohol, methyl-mercury, or maternal seizures activate a single gene,
HSF1, also known as heat shock factor, in cerebral cortex.
In addition, we reported the location of a functional binding site for IRF-1 (-744) in response to IFN-beta [22] and binding sites for heat shock factor 1 (
HSF1) (-459/-453) in response to heat-shock or arsenate treatments [77].
Additionally, gain of 8q24.3 (
HSF1)/8q24.21 (MYC), and 1q21-1q22 (MCL1), and loss of 9p21.3 (CDKN2A, CDKN2B, and MTAP) and 10q26qter (MGMT and EBF3) are associated with a shorter survival.
Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (
HSF1) activation in rheumatoid arthritis synovial tissue.
Heat shock response requires a specific transcription factor and in eukaryotes the critical regulator is heat shock factor,
HSF1. Its binding to the heat shock element (HSE) on DNA initiates the assembly of the transcription machinery.