| Acronym | Definition |
|---|
| HPR | High Performance Routing (APPN) |
| HPR | Host Plant Resistance (agriculture) |
| HPR | Harvard Political Review (Harvard University; Cambridge, MA) |
| HPR | High Performance Routing |
| HPR | High Performance Research Network |
| HPR | Home Page Reader |
| HPR | Home Page Reader (IBM Software) |
| HPR | Health Protection Report (publication; UK) |
| HPR | House of Pacific Relations (San Diego, CA) |
| HPR | Highly Protected Risk |
| HPR | High Performance Rule (sailboat handicapping) |
| HPR | Holding Period Return |
| HPR | Highest Previous Rate |
| HPR | HIV Prevention Research |
| HPR | Health Planning Region (various locations) |
| HPR | High Pressure Reactor |
| HPR | Hidden Point Removal (algorithm) |
| HPR | Health Program Representative (various locations) |
| HPR | Heritage Protection Reform (UK) |
| HPR | High-Point Rendel (UK) |
| HPR | High Powered Rocketry |
| HPR | High Priority Request |
| HPR | Hospital/Physician Relations |
| HPR | High Priority Recommendation (Australian) |
| HPR | Hiring Process Report |
| HPR | Hydro-acoustic Position Reference |
| HPR | Hunter, Pointer, Retriever (hunting dog) |
| HPR | Heave Pitch Roll (sensor) |
| HPR | Human Performance Reliability |
| HPR | High Pass Resolution Perimetry (computing protocol for measuring perimeter vision) |
| HPR | High Peak Rate |
| HPR | High Priority Requisition (Canadian Department of National Defence DND) |
| HPR | Hostes Populi Romani (Latin: Enemies of the Roman People, epigraphy) |
| HPR | Hardware Problem Report |