| Acronym | Definition |
|---|
| HSB | Hue, Saturation, Brightness (color model) |
| HSB | Hartford Steam Boiler (Hartford Steam Boiler Inspection and Insurance Company) |
| HSB | Harzer Schmalspurbahnen (Germany) |
| HSB | Hue Saturation Brightness |
| HSB | High Performance Serial Bus |
| HSB | Horizontal Scroll Bar |
| HSB | Hot Swap Backplane |
| HSB | Hanoi School of Business (Hanoi, Vietnam) |
| HSB | Heaven Shall Burn (band) |
| HSB | Head Start Bureau (Agency of the Department of Health and Human Services) |
| HSB | Horizontal Scroll Bar (Visual Basic prefix) |
| HSB | Humidity Sounder for Brazil (atmospheric humidity profile measurement instrument) |
| HSB | High Strength Bolt |
| HSB | Health Sciences Building |
| HSB | Haskayne School of Business (Canada) |
| HSB | Hardly Strictly Bluegrass (music festival; San Francisco, CA) |
| HSB | Health Services Bureau (various locations) |
| HSB | High Speed Bearing (grease; various companies) |
| HSB | Heart-Shaped Box |
| HSB | High-Speed Bus |
| HSB | High Surface Brightness (galaxies) |
| HSB | Harper Seven Beckham |
| HSB | Home and Small Business |
| HSB | Hyresgästernas Sparkasse- och Byggnadsförening |
| HSB | HarperCollins Study Bible |
| HSB | High School Bowl (Northern Michigan University) |
| HSB | Headquarters and Service Battery |
| HSB | Heavy Separate Brigade |
| HSB | Hot Stand By |
| HSB | High Speed Buffer |
| HSB | Houston Symphonic Band (Houston, TX) |
| HSB | Harbour Security Boats |
| HSB | Hic Situs Bonus (Latin: This Place Is Good, epigraphy) |