An innovative character of the dot blot, which was used in the present study, is in the fact that in the SSHL diagnostics, in addition to free Hsp70, the Hsp70 bound to circulating
immune complexes (CIC) is also searched for.
However, to date, primary CNS (genetic form) has not been reported with histopathological findings of
immune complex kidney disease.
Removal of factors like EMP, anti-neutrophil antibodies,
immune complexes, or superantigens could have been the important factor expediting recovery.
In our case, the first episode of nephrotic syndrome occurred with membranous LN (Class V), an
immune complex nephropathy; then a second episode occurred six years later with lupus podocytopathy, a nonimmune complex nephropathy.
On day 14, 21, 28 and 35, group A (
Immune complex Bursaplex) showed significantly higher GMT compared to vaccinated groups B and C.
In our case, there was diffuse crescentic necrotising GN without endocapillary proliferation and
immune complex deposition.
The presence or absence of
immune complex, either as granular deposits or as a linear coating of the basement membranes, is an important distinguisher in the classification system of small vessel vasculitis.
Peripheral ulcerative keratitis (PUK) is an autoimmune condition believed to involve complement system activation via
immune complexes in the peripheral cornea.
This phenomenon has been attributed to increased formation of oxLDL-specific
immune complexes [12].
Cornea and episclera are tissues with enhanced susceptibility to systemic inflammatory diseases, due to distinct local characteristics such as high vascular network of the conjunctiva and episclera, collagen riche-environment, and high number of Langerhans cells, immunoglobulin M (IgM), and complement C1, which favours
immune complex formation [1].
AD As will neutralize the drug rendering it ineffective or induce its rapid clearance through
immune complex formation.