Indole-3-carbinol prevents cervical cancer in human papilloma virus type 16 (HPV16) transgenic mice.
Chopping or chewing raw cruciferous vegetables allows enzymes in the food to convert glucosinolates to isothicyanates and
indole-3-carbinol. While all cooking methods reduce these compounds, steaming, microwaving and stir-frying result in less losses than boiling.
Preliminary results of the use of
indole-3-carbinol for recurrent respiratory papillomatosis.
Chen, "Antiobesity activities of
indole-3-carbinol in high-fat-diet-induced obese mice," Nutrition, vol.
A counterpart for the compound in broccoli, known as
indole-3-carbinol (I3C), was found after a chemical screening process.
There are other pharmaceutical agents and modalities currently being researched such as
indole-3-carbinol, retinoids, celecoxib, and targeted gene therapies.Indole-3-carbinol is a chemical found in vegetables such as broccoli, cabbage, and caulifower, and it has been shown to modulate HPV activity and reduce papilloma growth in studies conducted on animals.
Cruciferous vegetables, including broccoli, Brussels sprouts, cauliflower, and cabbage are especially good choices because they contain diindolylmethane (DIM), a metabolite of
indole-3-carbinol (I3C).
Rats exposed to cigarette smoke given
indole-3-carbinol, a phytochemical rich in cruciferous vegetables, had a lower lung cancer rate than those not given idole-3-carbinol (36).
CABBAGE King of the cruciferous family, cabbage contains the notable phytochemical that is thought to have anti-cancer properties:
indole-3-carbinol. The glucosinolates increase antioxidant protection and help detoxify harmful chemicals and hormones.
The main active components of cruciferous plants
indole-3-carbinol (I3C) and its derivatives such as 33'- Diindolylmethane (DIM) can inhibit cell proliferation and induce apoptosis of various tumor cells.
In 2011, British researchers determined that a compound called
indole-3-carbinol, found in cruciferous vegetables like broccoli, cabbage, and turnips, boosts the immune system and helps maintain intestinal health.