| Acronym | Definition |
|---|
| IRF | Interferon Regulatory Factor |
| IRF | Imposto de Renda na Fonte (Portuguese: Income Tax at Source) |
| IRF | International Religious Freedom |
| IRF | International Road Federation |
| IRF | Impulse Response Function |
| IRF | Inpatient Rehabilitation Facility (CMS) |
| IRF | Intelligent Resilient Framework (Hewlett-Packard) |
| IRF | Institut for Rationel Farmakoterapi (German) |
| IRF | Inherited Rights Filter |
| IRF | Inherited Rights Filter (Novell) |
| IRF | International Rhino Foundation |
| IRF | International Rectifier Corporation |
| IRF | India Radio Forum (India and Singapore) |
| IRF | International Rafting Federation |
| IRF | Intermediate Routing Function |
| IRF | Information Resource File |
| IRF | Institute of Retirement Funds |
| IRF | Interest Rate Future (finance) |
| IRF | Islamic Research Foundation |
| IRF | Information Retrieval Facility (Vienna) |
| IRF | Integrated Research Facility |
| IRF | Incident Report Form |
| IRF | Initial Response Force |
| IRF | Island Resources Foundation |
| IRF | Information Request Form |
| IRF | Institut für Roboterforschung (German) |
| IRF | Institute for Regional Forecasting (University of Houston) |
| IRF | International Renaissance Foundation |
| IRF | Institut für Religionsphilosophische Forschung (German: Institute for Philosophy of Religion) |
| IRF | Immediate Reaction Forces (NATO; US DoD) |
| IRF | Internal Relay Fault (transformers) |
| IRF | International Rogaining Federation |
| IRF | Individual Rights and Freedoms |
| IRF | Integer Register File |
| IRF | Information Retrieval Framework |
| IRF | International Ranger Federation |
| IRF | Integrated Regional Framework (UK) |
| IRF | International Racquetball Federation |
| IRF | Instrument Response Function |
| IRF | International Rail Forum |
| IRF | Institutionally Related Foundations (CASE conference) |
| IRF | Initial Reaction Force |
| IRF | Individual Rights Foundation |
| IRF | International Research Foundation |
| IRF | International Regulators Forum (Norway) |
| IRF | Interchange Reimbursement Fee (credit card processing) |
| IRF | Institute of Religious Formation (various locations) |
| IRF | Internal Requisition Form |
| IRF | In-Room Fitness (Program) |
| IRF | Immediate Response Forces |
| IRF | Internationale Ratten Fokkers/Fanclub (Dutch) |
| IRF | Institute of Robotics Research (University of Dortmund) |
| IRF | International Racing Federation |
| IRF | Institute for Rural Futures |
| IRF | Idaho Research Foundation (University of Idaho) |
| IRF | Inspectie der Rijksfinancien (Dutch) |
| IRF | Interdepartmental Recovery Fund (Canada) |
| IRF | Irrigation Research Foundation |
| IRF | International Ringette Federation |
| IRF | Istituto Ricerca e Formazione (Italian) |
| IRF | Incineration Research Facility (US EPA) |
| IRF | Informatik Roeing und Fritze (German) |
| IRF | International Relief Foundation |
| IRF | Intrinsic Random Function |
| IRF | International Religious Fellowship |
| IRF | Incorrect Read Fault |
| IRF | Internet Relay Forces |
| IRF | Iowa Retail Federation |
| IRF | Institutet for Rymdfysik (Swedish Institute of Space Physics) |
| IRF | International RustFest |
| IRF | India Renal Foundation |
| IRF | Information Reduction Factor |
| IRF | Internet Race Finder (online gaming) |
| IRF | Interference Reduction Factor (radio) |
| IRF | Iron Rod Found |
| IRF | Interreligiöses Forum Basel (German) |
| IRF | Internal Routing Form |
| IRF | Instituto del Riesgo Financiero (Spanish) |
| IRF | Instrument Response File |
| IRF | Installation Reuse Forum |
| IRF | International Real Fair |
| IRF | Interrogation Repetition Frequency (communications signalling) |
| IRF | Innovation and Research Focus |
| IRF | Interférences en Radio-Fréquences (French) |
| IRF | Invocation Request Form |
| IRF | Insurance Reinvestment Fund |
| IRF | Interaction Round the Face (quantum field theory) |
| IRF | Inter-Receiver Fairness (networking) |
| IRF | Intraretinal Fluid (ophthalmology |
| IRF | Inspektionsrauchfangkehrerfahrzeug (German) |
| IRF | Interpretation Request Form |
| IRF | Introduccion al Reconocimiento de Formas (Spanish) |
| IRF | Inside Right Forward (soccer) |
| IRF | Intrasis Raw File |
| IRF | Instrumentation Resources Facility |
| IRF | Interview Rating Form |
| IRF | Integrated Research File |
| IRF | Instructor Rating Form |
| IRF | International Roaming Facility |
| IRF | Institut de Recherche Fondamentale (French: Institute of Fundamental Research) |