Oral administration of
myelin basic protein is superior to myelin in suppressing established relapsing experimental autoimmune encephalomyelitis.
Mice doubly deficient in the genes for P0 and
myelin basic protein show that both proteins contribute to the formation of the major dense line in peripheral nerve myelin.
el-Fawal, "Autoantibodies to neurofilaments (NF), glial fibrillary acidic protein (GFAP) and
myelin basic protein (MBP) in workers exposed to lead," The Journal of the Egyptian Public Health Association, vol.
Sela, "Synthetic copolymer 1 and
myelin basic protein do not require processing prior to binding to class II major histocompatibility complex molecules on living antigen-presenting cells," Cellular Immunology, vol.
Weiner, "
Myelin basic protein and proteolipd protein reactivity of brain and cerebrospinal fluid-derived T cell clones in multiple sclerosis and postinfectious encephalomyelitis," Journal of Immunology, vol.
Dirucotide (MBP8298) is a synthetic replica of the molecular site on
myelin basic protein (MBP).
Spesifik olarak, periferik miyelindeki P1 proteini, santral
myelin basic protein (MBP) yapi olarak cok benzemekte olup immun yanit birinden digerine gecebilmektedir.
Myelin basic protein (MBP) is the second most abundant protein of myelin, the protective sheath formed around nerve axons in the central nervous system.
Tovaxin is an individualized T-cell therapeutic vaccine that consists of attenuated patient-specific myelin-reactive T-cells (MRTCs) against peptides of proteins from
Myelin basic protein (MBP), Myelin oligodendrocyte glycoprotein (MOG) and Proteolipid protein (PLP) or combinations thereof.
Cellular and humoral immune reaction against a variety of neural cell antigens, such as
myelin basic protein, myelin oligodendrocyte glycoprotein, myelin associated glycoprotein, ganglioside, sulfatide, and many other self-antigens, may result in a neuroimmune disorder including interference with neurotransmission.
This appears to be supported in animal model research where rats fed upon an iodine-deficient diet were found to have alterations in
myelin basic protein immunoreactivity and hence function.