Kaplan (1989) dubbed this syndrome the Deadly Quartet (obesity, HTN,
NIDDM, dyslipidemia), implying enhanced mortality due to associated CVD.
Presence of
NIDDM in a family member constitutes an established risk factor for
NIDDM.
Therefore, sulfonylureas used in combination with alpha glucosidase inhibitors demonstrate synergistic effects in lowering fasting and postprandial glucose levels in
NIDDM.
Consequently, Bell's group began to study other families prone to early-onset
NIDDM. In 1992, the researchers found that several of the families possess a mutant chromosome 12 gene that produces a defective enzyme involved in insulin's response to glucose (SN: 5/2/92, p.
Insulin resistance is present in individuals with impaired glucose tolerance and those with
NIDDM, which are common disorders.
* Black people have a higher prevalence of obesity, a strong risk factor for
NIDDM. Among people with diagnosed diabetes, 83 percent of adult black women are obese compared with 62 percent of white women and 45 percent of black men are obese compared with 39 percent of white men.
Relationship of generalized and original adiposity to insulin sensitivity in men with
NIDDM. Diabetes 1996;45:1684-93.
NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X.
Evaluation of GADA levels in individuals with non-insulin-dependent DM (
NIDDM) and their first-degree relatives can also be used as a predictor of late insulin dependency.
all controlled overweight
NIDDM patients (except pregnancy or nursing mothers) with frequent checking of BSLs is must.
A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of
NIDDM without altering glucose tolerance.
Onset of
NIDDM occurs at least 4-7 yr before clinical diagnosis.