(2000) Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking.
(1997) RanGTP-mediated nuclear export of karyopherin [alpha] involves its interaction with the nucleoporin Nup153.
Abbreviations: NPC: nuclear pore complex; SV40: simian virus 40; NLS: nuclear localization signal; cNLS: classical nuclear localization signal; NTR: nuclear transport receptor; Nup: nucleoporin; FG repeat: phenylalanine-glycine repeat; PTAC: nuclear pore-targeting complex; KPNA: karyopherin a; KPNB: karyopherin [beta]; IBB: importin [beta]-binding; Arm: armadillo.
In the new work, the researchers focused on one particular nucleoporin called Nup153, which is known to rapidly move on and off of the nuclear pore complex, suggesting it might be doing something other than providing structural support to the pore.
Mutations in many nucleoporin genes has been linked to human diseases and developmental disorders, including some forms of leukemia and inherited heart problems.
Jacinto et al., The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing.
Massague, "Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import," Journal of Biological Chemistry, vol.
The trafficking of molecules between the cytoplasm and the nucleus in eukaryotes is regulated by nuclear pore complexes (NPCs or nucleoporins), which are cylindrical structures containing about 100 different polypeptides and embedded in the double membrane of the nuclear envelope.
The importin-[alpha] interacts with importin-[beta] (also known as karyopherin-[beta]), which mediates the process of docking to the nucleoporins. The protein containing NLS is transported through NPC to the nucleus by importin [alpha]/[beta] heterodimeric complex.
The SET binding protein (SETBP1) is a SET regulator, and it is fused in frame with a
nucleoporin, NUP98.