| Acronym | Definition |
|---|
| OSG | Open Science Grid |
| OSG | Open Scene Graph |
| OSG | Overseas Shipholding Group, Inc (New York, NY) |
| OSG | Office of the Secretary-General (United Nations) |
| OSG | Official Strategy Guide (gaming) |
| OSG | Open System Group |
| OSG | Operational Support Group (US DoD) |
| OSG | Office of the Surgeon General (HHS - PHS) |
| OSG | Okasan Securities Group (Japan) |
| OSG | Open Systems Group |
| OSG | Opsec Security Group PLC |
| OSG | Operations Support Group |
| OSG | Orchid Specialist Group |
| OSG | Open Service Gateway |
| OSG | Oromia Support Group (UK) |
| OSG | On-Screen Graphics |
| OSG | Office of Student and Graduate Affairs (Singapore) |
| OSG | Objectivism Study Group |
| OSG | One Sweet Girl |
| OSG | Overspeed Governor |
| OSG | Operational Security Guideline |
| OSG | On-Screen Guide |
| OSG | Oberstabsgefreiter (German) |
| OSG | Oscillator Safeguard (microcontroller) |
| OSG | On-line Support Group |
| OSG | Osawa Screw Grinding (Toyokawa City, Japan) |
| OSG | Operating System Group |
| OSG | Overlapped Sub-Gridding |
| OSG | Optical Scene Generator |
| OSG | Osage Beach, Missouri - Municipal (airport code) |