France-based Ipsen and Servier have revealed preliminary data from the Phase 1/2 study of the investigational use of liposomal irinotecan (ONIVYDE) in combination with five- fluorouracil/leucovorin (5-FU/LV) and
oxaliplatin (OX) in study patients with earlier untreated metastatic pancreatic ductal adenocarcinoma cancer, at the ESMO 21st World Congress on Gastrointestinal Cancer in Barcelona, Spain it was reported yesterday.
Oxaliplatin is a platinum-based complex that binds preferentially to guanine and cytosine nucleotides, leading to the cross-linking of DNA and thus blocking DNA replication and transcription.
As ESC was diminished in our OIPN patients with painful symptoms, this study suggests that
oxaliplatin could impair small nerve fibers.
For example, by the third treatment cycle, cold temperatures (5-20[degrees]C) that were perceived as somewhat noxious before the start of
oxaliplatin treatment are now perceived as painful ("cold hyperalgesia") following
oxaliplatin treatment [16].
A total of 72 patients, who had received adjuvant
oxaliplatin chemotherapy following the radical resection of histologically confirmed stage II (T2 and T3, N0, M0) or stage III (any T, N1 and 2, M0) CCa, were recruited from the Department of Medical Oncology in the First Affiliated Hospital of Medical College of Shihezi University during June 2014 and March 2017.
She was started on combination chemotherapy with
oxaliplatin and CAPOX.
This patient received adjuvant chemotherapy composed of oral S-1 75 mg twice daily for 14 days plus
oxaliplatin 0.2 g once intravenously, without radiotherapy.
In order to obtain new Pt(IV) complexes with different number of bexarotene moieties as axial ligands, we used Pt(IV) analogs of
oxaliplatin and the acid chloride of bexarotene (Scheme 3).