Pregnane X receptor (PXR): PXR turns on sulfation in phase 2 detoxification, regulating the processing of xenobiotic and endogenous compounds.
A significant correlation has been found between hepatic CYP2E1 activity and nocturnal hypoxia.[10] We had previously reported that rats exposed to IH and cigarette smoke exhibited an increase of hepatic inflammatory cytokines, a reduction of CYPs, and a decrease of the nuclear receptors
pregnane X receptor (PXR), constitutive androstane receptor (CAR), and glucocorticoid receptor (GR).[11] Therefore, we hypothesized that IH-associated inflammation will independently lead to liver injury, which may further be exacerbated by another hepatic insult.
Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and
pregnane X receptor (PXR).
Pregnane X receptor suppresses proliferation and tumourigenicity of colon cancer cells.
A role for the
pregnane X receptor in flucloxacillin-induced liver injury.
Human nuclear
pregnane X receptor cross-talk with CREB to repress cAMP activation of the glucose-6-phosphatase gene.
Many EDCs, including organochlorine and organophosphate pesticides, alkylphenols, phchalates, and polychlorinated biphenyls (PCBs) activate another nuclear receptor, the
pregnane X receptor (PXR; also known as steroid and xenobiotic receptor, or SXR) (Zhou ct al.
The
pregnane X receptor (PXR, also known as NR1I2, SXR, or PAR) is a nuclear hormone receptor (NHR) that regulates the transcription of genes involved in xenobiotic metabolism and excretion.
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors.
Scientists already knew that when PCBs bind to the
pregnane X receptor (PXR) in rodents, the ligand-bound receptor elicits production of enzymes that metabolize PCBs and other contaminants.
The mammalian xenobiotic response is mediated primarily by two broad-specificity sensors: the orphan nuclear receptors SXR/PXR (human steroid and xenobiotic receptor/rodent
pregnane X receptor) (Blumberg et al.