Namely, importin [alpha] can bind to spindle assembly factors to form a stable ternary complex with importin [beta]1 to inhibit their function in the cytoplasm; however, around mitotic chromosomes, where the RanGTP concentration is high due to the presence of
RCC1, (45, 46) the binding of RanGTP to importin [beta]31 triggers the dissociation of importin [beta]1 and importin [alpha] from spindle assembly factors, leading to local activation of the spindle assembly factors.
RIOK3 (5.00; P [less than or equal to] 0.0001) and
RCC1 (5.32; P [less than or equal to] 0.0002)are thetop significant genes associated with cytoskeletal architecture and the cellular transport mechanism.
They were thioredoxin superfamily protein (Glyma04g42080; DR)/SEUSS transcriptional coregulator (Glyma06g12720; UR), and regulator of chromosome condensation (
RCC1) family protein (Glyma04g08940; UR)/protein of unknown function (DUF810) (Glyma06g09020; DR).
He termed that
RCC1 set an example for other Chambers of the country to organize such Expos to promote Pakistani products in other countries of the world.
Makde, a postdoctoral member of the research team led by Tan, grew molecular crystals of the protein
RCC1 (regulator of chromosome condensation, a protein critical for proper separation of chromosomes during cell division) bound to the nucleosome, and used X-ray crystallography to determine the atomic structure of the complex.