| Acronym | Definition |
|---|
| RPU | Regional Premier Upgrade (airlines promotion) |
| RPU | Redundant Power Unit |
| RPU | Rochester Public Utilities (Rochester, NY) |
| RPU | roadster pickup |
| RPU | Reduced Paid-Up (Insurance) |
| RPU | Revenue Per User (telecommunications) |
| RPU | Remote Processing Unit |
| RPU | Remote Pickup |
| RPU | Related Product Unit |
| RPU | Road Policing Unit (UK) |
| RPU | Revenue Per Unit |
| RPU | Ray Processing Unit (computer graphics; ray tracing) |
| RPU | Rebate per Unit (Medicaid) |
| RPU | Rhino Protection Unit |
| RPU | Routing Process Unit |
| RPU | Résumé de Passage aux Urgences (French: Emergency Passage Summary) |
| RPU | Remote Pickup Unit |
| RPU | Reconnaissance, Patrol and Utility Vehicle |
| RPU | Radio Phone Unit (US Navy) |
| RPU | Radiological Preparedness Unit (California Office of Emergency Services) |
| RPU | Receiver Processor Unit |
| RPU | Rational Product Updater (IBM) |
| RPU | Registered Publication Unit (US Navy) |
| RPU | Revenue Protection Unit |
| RPU | Ryerson Polytechnic University |
| RPU | Regional Processing Unit |
| RPU | Reception Processing Unit (military personnel) |
| RPU | Repair-Parts-Upgrades (Miami, FL) |
| RPU | Rotor Phasing Unit |
| RPU | Radar Pressurization Unit |
| RPU | Riverside Public Utility (Riverside, CA) |