| Acronym | Definition |
|---|
| SMU | Singapore Management University |
| SMU | Southern Methodist University |
| SMU | Saint Mary's University (Halifax, Nova Scotia; Philippines) |
| SMU | Solid (Waste) Management Unit |
| SMU | Saint Mary's University of Minnesota |
| SMU | Sikkim Manipal University (India) |
| SMU | Suomen Merimies-Unioni (Finnish: Finnish Seamen's Union) |
| SMU | Sindicato Médico del Uruguay |
| SMU | Storage Migrator for Unix |
| SMU | Shanghai Maritime University (Shanghia, China) |
| SMU | Santa Monica United (soccer; California) |
| SMU | Swansea Metropolitan University (UK) |
| SMU | Sekolah Menengah Umum (Indonesian High school) |
| SMU | Special Management Unit |
| SMU | Services Médicaux d'Urgence (French: Emergency Medical Services) |
| SMU | Southern Mississippi University |
| SMU | Special Mission Unit (US DoD) |
| SMU | System Management Utility |
| SMU | Smallest Mining Unit |
| SMU | Start Me Up |
| SMU | Southeastern Massachusetts University (formerly used, now Umass) |
| SMU | Source Measurement Unit |
| SMU | Storage Management Utility (data storage) |
| SMU | Special Make Up |
| SMU | Selective Mining Unit |
| SMU | System Managed Undo (Oracle Databases) |
| SMU | Sociedad Mexicana de Urología |
| SMU | Sediment Management Unit |
| SMU | Supply Management Unit |
| SMU | Sassy Management Unit |
| SMU | Small Marching Unit |
| SMU | Switch Multiplexer Unit |
| SMU | Secure Mobile Unit |
| SMU | Service Meter Unit |
| SMU | Scrutin Majoritaire Uninominal (French: Single Member Plurality) |
| SMU | Service Management Unit |
| SMU | Strategic Market Unit |
| SMU | Switch Multiplex Unit |
| SMU | Svenska Missionskyrkans Ungdomsförbund (Swedish Christian Youth Organisation) |
| SMU | Secours Médical d'Urgence (French: Emergency Medical Relief; various organizations) |
| SMU | Storage Management Unit |
| SMU | Subscriber Module Urban |
| SMU | Single-Word, Multiple-Bit Upset |
| SMU | Speaker/Microphone Unit (US NASA) |
| SMU | Software Maintenance Update (Cisco) |
| SMU | System Master Unit |
| SMU | Sindh Madressah University (Karachi, Pakistan) |
| SMU | Space Management Utility |
| SMU | Shelter Management Unit (US FEMA) |
| SMU | Small and Medium-Sized Undertaking |
| SMU | Space Self Maneuvering Unit |
| SMU | Simple Mail Users |
| SMU | System Measurement Unit |
| SMU | Secours Mondial d'Urgence (French: World Emergency Relief) |
| SMU | Super Module Unit |
| SMU | Super Millionaire University (fictional, from TV show Gilligan's Island) |
| SMU | Smoke Me Up |
| SMU | Special Maintenance Unit (India) |
| SMU | Safe Mode Utility |