Apoptosis-inducing effect of a palladium(II) saccharinate complex of
terpyridine on human breast cancer cells in vitro and in vivo.
The structure, an alternated copolymer of fluorene and
terpyridine, namely, poly[(9,9-bis(3-((S)-2- methylbutylpropanoate))fluorene-alt-6,6'-(2,2':6' ,2" terpyridin-6-yl)] (LaPPS71), is depicted in Figure 1.
Weyhermuller et al., "Novel mononuclear Cu (II)
terpyridine complexes: Impact of fused ring thiophene and thiazole head groups towards DNA/BSA interaction, cleavage and antiproliferative activity on HepG2 and triple negative CAL-51 cell line," European Journal of Medicinal Chemistry, vol.
In particular, our interests are concerned in terthiophenes bearing free and complexed nitrogen ligands (
terpyridine or phenanthroline) [13-16].
The polystyrene-based
terpyridine polymer was prepared from 4-chloromethyl styrene [9].
Using
terpyridine molecules to create the framework and zinc atoms as a structural glue, the molecules form structures that are able to self-assemble, giving it the ability to automatically heal after a break.
The coordinated nitrogen atom of the central pyridine unit of tridentate ligand of complex 4 has the lowest spin-spin coupling among all its coordinated nitrogen of the ligands while no significant variation is observed for the three coordinated nitrogen atoms of the
terpyridine unit of complex 5.
A difficult synthesis of modified
terpyridine ligands is one of the major factors.
Terpyridine was discovered in 1931, they say, and has been shown to lend itself to the construction of specific, stable metal complexes with unique properties that can easily be tuned by the choice of the metal ion and/or the structural modification.