| Acronym | Definition |
|---|
| DE | Germany (Deutschland; Internet top level domain) |
| DE | Delaware (US postal abbreviation) |
| DE | Desktop Environment |
| DE | Deutsch (German) |
| DE | Deutschland (German: Germany) |
| DE | Dead End |
| DE | Data Engineering |
| DE | Dark Energy |
| DE | Driver Education |
| DE | Desert Eagle |
| DE | Data Entry |
| DE | Diesel Engine |
| DE | Diesel-Electric |
| DE | Director of Education |
| DE | Digital Electronics |
| DE | Derby (postcode, UK) |
| DE | Development Engineer |
| DE | Data Element |
| DE | Design Engineer |
| DE | Double Ended (metal halide lamps) |
| DE | Deus Ex (game) |
| DE | Defensive End (football) |
| DE | Distance Education (course; various schools) |
| DE | Destroyer Escort |
| DE | Differential Equation(s) |
| DE | Department of Education (US) |
| DE | Digital Environment |
| DE | Discrete Event (program specification) |
| DE | Directed Energy |
| DE | Double Edge (shaving) |
| DE | Dale Earnhardt |
| DE | Dark Elf |
| DE | Diesel Exhaust |
| DE | Detonation |
| DE | This is / From (Amateur Radio logging abbreviation) |
| DE | Drive End |
| DE | Detection Efficiency |
| DE | Digital Engineering |
| DE | Density Evolution |
| DE | Distinguished Engineer (various organizations) |
| DE | DiplĂ´me d'Etat (French: state diploma) |
| DE | Dail Eireann (Irish National Parliament) |
| DE | Donor Egg (infertility; refers to IVF) |
| DE | Diatomaceous Earth (filter) |
| DE | District Engineer |
| DE | Dose Equivalent |
| DE | Donee (IRB) |
| DE | District Executive |
| DE | Daily Egyptian (student newspaper; Carbondale, IL) |
| DE | Directed Evolution |
| DE | Dragon Empires (game) |
| DE | Delayed Extraction |
| DE | Design Estimate |
| DE | Death Eater (Harry Potter) |
| DE | Disenchant (gaming, World of Warcraft) |
| DE | Delay Equalizer (US DoD) |
| DE | Depth Electrode |
| DE | Dark Eldar |
| DE | Developer Evangelist (Microsoft) |
| DE | Domain Engineering |
| DE | Display Element |
| DE | Data Exclusivity |
| DE | Distinguished Editor (Institute of Professional Editors) |
| DE | Digital Empire |
| DE | Digital Encoder |
| DE | Doctor of Engineering |
| DE | Decentralized Execution (US DoD) |
| DE | Distant End (satellite communications) |
| DE | Dedicated Equipment |
| DE | Defense Emergency |
| DE | Delegated Examining |
| DE | Distribution Engineering |
| DE | Dry End |
| DE | Debugging Extension (computing) |
| DE | Destruction Efficiency |
| DE | Data Encoder |
| DE | Dictation Equipment |
| DE | Device End |
| DE | Defense Enterprise (GIG) |
| DE | Divisional Engineer |
| DE | Deep Etch |
| DE | Discard Eligibility (ATM) |
| DE | Darkness Eternal (website) |
| DE | Diethylene Glycol Monoethyl Ether |
| DE | Dynamics Explorer |
| DE | Development Ephemeris (Jet Propulsion Laboratory) |
| DE | degree of esterification |
| DE | Designated Examiner |
| DE | Development Estimate |
| DE | Discipline Engineer |
| DE | Digital Exploitation |
| DE | Decision Element |
| DE | Designated Engineer |
| DE | Digital Enclosure |
| DE | Display Entity |
| DE | Individual Drift Error (US DoD) |
| DE | Damage Expectancy |
| DE | Doppler Extractor (US NASA) |
| DE | Draconian Empire (gaming) |
| DE | Dissemination Element |
| DE | Condor Flugdienst GmbH, Germany (IATA airline code) |
| DE | Divisions Exercise |
| DE | Division/District Engineer (Army Corps of Engineers) |
| DE | Disposable Excess |
| DE | Drums Equivalent |
| DE | Total Drift error |
| DE | Deployment Echelon |
| DE | Assault Personnel Destroyer |
| DE | DCS/Engineering & Services |