The affected Drospirenone and
Ethinyl Estradiol Tablets were identified as Lot number 183222, with NDC number 59746-763-43 and expiration date of 11/2020.
Segesterone acetate blood levels decreased only slightly over six months of use in a prior clinical trial with a progestin only ring, and when
ethinyl estradiol was added to the ring, segesterone acetate blood levels were unchanged.
Comparison of cOCPs (having
ethinyl estradiol 30 mcg/ desogestrel 150 mcg) plus spironolactone with cOCPs (containing
ethinyl estradiol 35 mcg/ cyproterone acetate 2 mg) was done by Leelaphiwat et al and it showed improvement in mFG score from 4.27 +- 1.94 to 4.07 +- 1.91 in the combination group after 3 months of treatment18.
Plasma concentrations of norelgestromin and
ethinyl estradiol were identical over time in the OC and OC + DMF groups in period 1, as was serum progesterone.
A one-year, open-label, randomized controlled trial compared the safety of the combined contraceptive vaginal ring with a combined oral contraceptive containing 30 [micro]g
ethinyl estradiol and 150 [micro]g levonorgestrel 6 or 3 mg drospirenone (9).
The researchers found that, compared with women not using hormonal contraception, the relative risk of confirmed VTE in users of OCs containing 30-40 mcg of
ethinyl estradiol with levo-norgestrel was 2.9 (95% confidence interval, 2.2-3.8), compared with 6.6 in women using OCs containing desogestrel (95% CI, 5.6-7.8), 6.2 in users of gestodene (5.6-7.0), and 6.4 in women taking drospirenone (5.4-7.5).
John's wort with the OC was associated with a significant increase in the clearance of norethindrone and a significant reduction in the half-life of
ethinyl estradiol. Oral clearance of midazolam was significantly increased during the herb usage, but the systemic clearance of midazolam was stable with no change.
One study showed a 29 percent decrease in levels of
ethinyl estradiol and an 18 percent decrease in levels of norethindrone in women taking nevirapine while using a COC containing these hormones.
Extended use of transdermal norelgestromin/
ethinyl estradiol: a randomized trial.
ER agonists include the pesticide methoxychlor, certain polychlorinated biphenyls (PCBs), bisphenol A (BPA; a high production volume chemical used to make polycarbonate plastic), pharmaceutical estrogens such as diethylstilbestrol (DES) and
ethinyl estradiol, and phytoestrogens, which occur naturally in many plants, most notably in soybeans in the form of genistein and related substances.
A total of 26 women, aged 18-45 years, were randomized to a double-blind treatment with an oral contraceptive containing drospirenone and
ethinyl estradiol (Yasmin).
Women in the emergency contraceptive group received one regimen of emergency contraceptive pills (containing levonorgestrel and
ethinyl estradiol), a five-minute educational session on how to use the method and an educational brochure; women in the control group received only the standard counseling given to all women prior to discharge.