The aim of this study was to study efficacy of intratympanic
gentamicin as a treatment protocol in Meniere's disease with intractable vertigo, to compare the degree of sensorineural hearing loss in all treated patients with intratympanic
gentamicin and to compare the collected data with available world literature.
Other molecular changes in the skin, such as increased expression and polarization of beta4 integrin, were consistent with the ability of
gentamicin to address the underlying pathophysiology of H-JEB.
Following a stabilization period with the control solution, the cell monolayer was exposed for 10, 20, and 30 min to a control solution containing 0.1 mM
gentamicin sulfate (Santa Cruz Biotechnology, USA) with a recording period of about 1 min.
The results in Table I display a significant difference in mean serum urea level between the normal newborn group and the
gentamicin treated group: the treated group had an increase in urea levels.
MIC of 45 isolates which were resistant to
gentamicin by disc diffusion method was as follows: 37 resistant isolates (83%) and 8 sensitive isolates (18%).
He received IV
gentamicin 230 mg (3.07 mg/kg ideal bodyweight) and IV vancomycin 2000 mg (17.12 mg/kg) within 30 minutes prior to first incision.
In the IHC basal pole region,
gentamicin treatment induced a significant decrease in the number of ribbons (13.30 [+ or -] 0.37, 6.40 [+ or -] 0.37, and 4.20 [+ or -] 0.23 in the control, 4-day
gentamicin, and 7-day
gentamicin groups, resp.) (Figure 4(e) and Supplementary Table 1).
During the past 6 to 8 years, a number of research scientists have produced a large experimental data that helped us understand the pathogenesis of nephrotoxicity.1
Gentamicin is one of the most commonly used antibiotic for the treatment of gram negative bacterial infections.2
Gentamicin is potentially effective drug against gram positive bacterial infections and also used in the treatment of infected wounds, burns and skin lesions.3
Whatley et al have reported on the proposed risk of systemic absorption in ENT patients undergoing nasal irrigations with
gentamicin. (5)
But only IT
gentamicin led a significant hearing loss in HHP.
For severe penicillin or cephalosporin allergy in pregnancy, use
gentamicin 240 mg, single intramuscular dose plus azithromycin 2 g, single oral dose.
Gentamicin (Genticyn) 80 mg injection manufactured by Abbott Healthcare Pvt.