| Acronym | Definition |
|---|
| HDC | Half Double Crochet |
| HDC | Historic District Commission (various locations) |
| HDC | Hill Descent Control (automobiles) |
| HDC | Home Design Center (various locations) |
| HDC | Housing Development Corporation (New York, NY) |
| HDC | High-Dose Chemotherapy |
| HDC | Hot Dog Cart |
| HDC | Hastings District Council (New Zealand) |
| HDC | Harborough District Council (UK) |
| HDC | Hard Disk Crusher (various companies) |
| HDC | High Density Distribution Chassis |
| HDC | High Definition Camera |
| HDC | Hardware Data Compression |
| HDC | Hill Descent Control |
| HDC | Hybrid Device Controller |
| HDC | High Dependability Computing |
| HDC | Handle to a Device Context |
| HDC | Horsham District Council (UK) |
| HDC | Histidine Decarboxylase |
| HDC | Hard Disk Controller |
| HDC | Horowhenua District Council (New Zealand) |
| HDC | Help Desk Central (Texas A&M University) |
| HDC | High Desert Church |
| HDC | Home Detention Curfew (UK criminal system) |
| HDC | Heavy Duty Chassis (vehicles) |
| HDC | Hold-Down Clip (various companies) |
| HDC | Heartland Developers Conference (software) |
| HDC | Henry Dunant Centre (conflict resolution) |
| HDC | Horticultural Development Council (UK) |
| HDC | Health & Disability Commissioner (New Zealand) |
| HDC | High Dependency Care (healthcare) |
| HDC | Hors de Combat (French: Outside the Fight) |
| HDC | Holder in Due Course (legal) |
| HDC | Health Data Consortium |
| HDC | Health Discovery Corporation (molecular diagnostics; Savannah, GA) |
| HDC | Homier Distributing Company (Huntington, IN) |
| HDC | Hard Drive Carrying (case) |
| HDC | Hard Drive Crash |
| HDC | Hydrodynamic Chromatography (analytical chemistry) |
| HDC | Honeysuckle Development Corporation (New South Wales; Australia) |
| HDC | Heart and Diabetes Center (Germany) |
| HDC | Hydroelectric Design Center (US Army Corps of Engineers) |
| HDC | Help Defeat Cancer (project) |
| HDC | Hotel del Coronado |
| HDC | Historic Development Commission (Alabama) |
| HDC | Helicopter Direction Center |
| HDC | Hensall District Cooperative (Canada) |
| HDC | High Density Connector |
| HDC | Higher Diploma Course (various locations) |
| HDC | Harbor Defense Command |
| HDC | Hollandse Dagblad Combinatie |
| HDC | Heartland Deaf Center, Inc. |
| HDC | Harbor Defense Commander |
| HDC | Hackers Dot Com |
| HDC | Hasselblad Data Camera |
| HDC | Habitability Design Center (US NASA) |
| HDC | Hardwoods Development Council (Pennsylvania Department of Agriculture; Harrisburg, PA) |
| HDC | Hardware Design Center |
| HDC | Handle for Device Context (Microsoft Windows programming) |
| HDC | Houston Dow Center |
| HDC | Hotel Development Council |
| HDC | Hackers Digital Crime (German) |
| HDC | Hybrid Driver Controller |
| HDC | Historical Data Collection (IBM) |
| HDC | Helicopter Defense Command |
| HDC | Helicopter Director Center |
| HDC | Hijo del Cura (Spanish) |
| HDC | Hawkins Data Center (California DOJ) |
| HDC | Henry Dryden Collection (art; UK) |
| HDC | Harmonie de Charlesbourg |
| HDC | Helicopter Dynamic Component |
| HDC | Health and Development Centre (various locations) |
| HDC | Harmonie de Coaticook |