The 196 patients in the trial had relapsed multiple myeloma, were refractory to an
immunomodulatory drug, a proteasome inhibitor, and to treatment with an anti-CD38 antibody.
The cancer often becomes resistant to treatment, and indeed patients in Dreamm-2 were refractory to anti-CD38 antibody treatment, an
immunomodulatory drug, and a proteasome inhibitor.
The randomised, open-label, multicentre Phase 3 study included 522 patients with multiple myeloma who had received at least three prior lines of therapy including a proteasome inhibitor and an
immunomodulatory drug, or whose disease was refractory to both a PI and an IMiD (median age of 67).
The company's randomised, open-label, multicenter Phase 3 COLUMBA study included 522 patients with multiple myeloma, who had received at least three prior lines of therapy including a proteasome inhibitor (PI) and an
immunomodulatory drug (IMiD), or whose disease was refractory to both a PI and an IMiD.
Patients were randomised to receive either daratumumab in combination with lenalidomide (an
immunomodulatory drug) and dexamethasone (a corticosteroid) or lenalidomide and dexamethasone alone.
It also has different roles in
immunomodulatory drug treatment of cancer patients.
Further studies are required to investigate the possible effects of long-term
immunomodulatory drug use on both atrophy and neurodegeneration and the effects of this neurodegeneration on the clinical picture.
Neither topical pimecrolimus (an
immunomodulatory drug) nor jewelweed extract are helpful (SOR: B, 1 small randomized controlled trial [RCT]).
Unfortunately, nodules eventually developed in her right breast, and she was started on dexamethasone and lenalidomide; the latter is a member of a newer class of
immunomodulatory drug. Yet her disease continued to progress, and 14 months after diagnosis of her disseminated disease, she was started on palliative radiotherapy.
The company's
immunomodulatory drug discovery activities support its pipeline of therapeutic candidates.