Rates of
loss of heterozygosity and mitotic recombination in NF2 schwannomas, sporadic vestibular schwannomas and schwannomatosis schwannomas.
(8) However, these findings contrast with more recent results from molecular studies using DNA sequencing and
loss of heterozygosity analysis.
Loss of heterozygosity in skin fibroblasts from heterozygous [alpha]GT KO piglets
In relation to its function, it is known that KLF6 is a tumor suppressor, also inactivation either by
loss of heterozygosity (LOH), somatic mutation or methylation of its promoter, leads to the development of various types of cancers such as prostate, colon, gliomas and hepatocellular carcinoma (Di Feo et al., 2009).
However, the complete
loss of heterozygosity of chromosome 1 in this patient suggests that monosomic rescue or mitotic error were the two most likely mechanisms of the observed UPD.
The wing somatic mutation and recombination test (SMART) using Drosophila melanogaster was developed to detect
loss of heterozygosity in suitable gene markers that express detectable phenotypes in wing cells.
Happle (1991) suggested that the
loss of heterozygosity in somatic cells during early embryogenesis results in somatic recombination with daughter cells.
KRAS mutations have been identified in 70% of cases and
Loss of Heterozygosity (LOH) at 5q22, 6q, 17p13, and 18q21 are also identified.
Generally, all forms of agminated nevi likely result from a
loss of heterozygosity (LOH) mutation in the somatic line of an embryo, inducing a localized predilection for the development of nevi.
Croce's group focused its efforts on this region and used a genetic approach called
loss of heterozygosity (LOH) to narrow the region of loss and identify the altered gene(s) involved in CLL.
This may also suggest that similar demographic situations were occurring separately in both populations; for instance, the multiethnic assemblage, cosmopolitan effects, inbreeding in the population isolates, and
loss of heterozygosity.