The delivery of
melphalan through the intra-arterial route is a clinically practiced therapy for treatment of retinoblastoma [11, 12, 16-18], but it has been shown to cause multiple adverse effects locally.
The patients received high-dose
melphalan treatment and autologous blood stem-cell transplantation.
(32) Patients typically receive high dose
melphalan 200 mg/[m.sup.2] (140 mg/[m.sup.2] in renal dysfunction).
High-dose
melphalan and autologous stem-cell transplantation in patients with AL amyloidosis: an 8-year study.
The patient was treated with intravenous
melphalan for two consecutive days at a total dose of 140 mg/[m.sup.2].
In comparison, another group given
melphalan and prednisone alone survived 33.2 months.
On the other hand, high-dose
melphalan followed by stem cell rescue leads to CR rates of up to 60% and prolongs overall survival up to 7 years.
All patients also were treated with
melphalan 200 mg/[m.sup.2] and autologous stem cell transplant (ASCT).
To be eligible for consideration for HITH care patients must be undergoing autologous HSCT following either LACE (Lomustine, Cytosine Arabinoside, Cyclophosphamide and Etoposide) or
melphalan conditioning, give informed consent, be over 18 years of age, medically stable, have available appropriate carer supervision, have a suitable home environment; be able to use their own toilet and administer their own oral medication, have access to a home telephone and available transport and be compliant with therapy.
He and other Geron researchers tested the anticancer drug
melphalan (marketed as Alkeran) and an anti-telomerase agent on mice with melanoma, a lethal skin cancer.
After 12 weeks, he was placed on six cycles of maintenance treatment with 1 mg/kg of
melphalan for 10 days and 60 mg of prednisone tapered over 5 days.
After 4 years when his cancer was in remission, in September 1995, the disease recurred (stage IVa) for which he received several more courses of chemotherapy, according to protocols BEAM (carmustine, etoposide, cytarabine,
melphalan) and CEP (lomustine, etoposide, prednimustine).