| Acronym | Definition |
|---|
| OSR | Office of State Revenue (Australia) |
| OSR | Old School RuneScape (video game) |
| OSR | Offshore Special Regulations (International Sailing Federation) |
| OSR | Office Service Release |
| OSR | Oracle Service Registry |
| OSR | Optical Switch Router |
| OSR | Oilseed Rape |
| OSR | OEM Service Release |
| OSR | Orchestre de La Suisse Romande |
| OSR | Ontario Student Record |
| OSR | Outside Sales Representative |
| OSR | Office of School Readiness (various locales) |
| OSR | Open Systems Resources, Inc (Amherst, NH) |
| OSR | Oil Spill Response |
| OSR | Operational Sex Ratio (biology) |
| OSR | Operating Systems Review (ACM) |
| OSR | Oversampling Ratio |
| OSR | Ohio State Reformatory |
| OSR | Office of Scientific Research |
| OSR | Old San Antonio Road |
| OSR | Overseas Service Ribbon |
| OSR | Optical Solar Reflector |
| OSR | Open Source Religion |
| OSR | Onward Supply Relief (value added tax) |
| OSR | One Seat Ride (transportation) |
| OSR | Open Space Reservation (Indian real estate) |
| OSR | Ontario Stroke Registry (Canada) |
| OSR | Overall Stripping Ratio (mining) |
| OSR | Organization Systems Renewal |
| OSR | Optical Scanning Recognition |
| OSR | Off Side Rear (automotive engineering) |
| OSR | Optical Symbol Recognition (computing) |
| OSR | Organization for SETV Research |
| OSR | Ontario Southland Railway, Inc. |
| OSR | Optical Service Router (Cisco Systems) |
| OSR | Operational Safety Requirement |
| OSR | Offensive Success Rate (sports) |
| OSR | Operational Safety Review |
| OSR | On-Site Representative |
| OSR | Optimized Set Reduction |
| OSR | Oxidative Stress Relief |
| OSR | Ocean State Republican (Rhode Island) |
| OSR | One-Shot Rising |
| OSR | Office of Systems Requirements |
| OSR | Occupational Survey Report |
| OSR | Ostrava Mosnov Czech Republic (airport code) |
| OSR | Official Site Register |
| OSR | Organisation Syndicale Représentative |
| OSR | Ockanickon Scout Reservation (Pennsylvania Boy Scout Camp) |
| OSR | Optical Subrack |
| OSR | Onteora Scout Reservation (Livingston Manor, NY) |
| OSR | On-Scene Representative |
| OSR | Over Subscription Ratio |
| OSR | Optimized Sniper Rifle (LaRue Tactical) |
| OSR | One Step Routing |
| OSR | Office of Standards and Regulation |
| OSR | Officer Selection Report |
| OSR | Optimum Sonar Routing |
| OSR | Outlet Sales Report |
| OSR | Oscillator Statistics Request |
| OSR | Order of the Silver Ribbon |
| OSR | Office Sonégien de Radiodiffusion (French: Sonégien Broadcasting Office; Belgium) |
| OSR | Operational Support Requirement |
| OSR | Out of Service Repair Tag (mining maintenance industry for sending repairable items off site and keep) |
| OSR | Original Sound Record Co. (record label) |