Redox modification of
ryanodine receptors contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure.
In patients suffering from
Ryanodine Receptor Type 1 Related Myopathies (RYR1-RM), the common symptoms include ophthalmoparesis and muscle weakness, typically affecting the proximal muscle.
"I'm interested in stopping defective
ryanodine receptor channels from leaking and my current BHF-funded grant involves looking at ways we might achieve that."
"I'm interested in stopping defective
ryanodine receptor channels from leaking, and my current BHF-funded grant involves looking at ways we might achieve that."
(4,5) N-methyl-D-aspartate (NMDA) and
ryanodine receptors are important cellular mechanisms that substantially contribute to the modulation of intracellular calcium.
MacQuaide, "The direct actions of flecainide on the human cardiac
ryanodine receptor: keeping open the debate on the mechanism of action of local anesthetics in CPVT," Circulation Research, vol.
Zorzato, "Congenital muscle disorders with cores: the
ryanodine receptor calcium channel paradigm," Current Opinion in Pharmacology, vol.
Abbreviations DM: Diabetes mellitus CVDs: Cardiovascular diseases T2DM: Type 2 diabetes mellitus GK: Goto-Kakizaki GLUT-2: Glucose transporter GPDH: Glycerol-3-phosphate dehydrogenase NZO: New Zealand obese OLETF: Otsuka Long Evans Tokushima Fat SDT: Spontaneously diabetic Torri TGF-[beta]1: Transforming growth factor-[beta]1 ECM: Extracellular matrix PKB: Protein kinase B ECC: Excitation-contraction coupling SR: Sarcoplasmic reticulum RyR:
Ryanodine receptor CICR: Calcium-induced calcium release SERCA2: SR [Ca.sup.2+]-ATPase2 NCX: [Na.sup.+]/[Ca.sup.2+] exchanger ENDO: Endocardial EPI: Epicardial.
Rickard, "Pharmaco-behavioural evidence indicating a complex role for
ryanodine receptor calcium release channels in memory processing for a passive avoidance task," Neurobiology of Learning and Memory, vol.
Missense variants in the cardiac
ryanodine receptor encoding the
ryanodine receptor 2 (RYR2) gene are detected in approximately 50% of CPVT probands (17-19).