However, the influences of HLA haplotypes on aGVHD
have been rarely studied.
The successful outcome of the DSMB interim analysis using the trial's primary endpoint of Day 28 overall response is consistent with previously reported results in a pediatric Expanded Access Program (EAP) in children with steroid-refractory aGVHD
The company plans to expand its use in adult patients with high-risk steroid-refractory aGVHD
It is thought that both donor-derived alloreactive T cells similar to AGVHD
and autoreactive T cell clones which can not be deleted as a result of thymic damage are involved (66, 67).
performed yet another study which sought to evaluate the use of ECP as second line therapy in patients with steroid-refractory aGvHD
cGVHD can occur anytime from months to years after AHSCT and may or may not be preceded by episodes of aGVHD
To support filing of a biologic license application to the FDA for regulatory approval, Mesoblast is conducting a 60-patient, open label Phase 3 trial using MSC-100-IV as front-line therapy in children with steroidrefractory aGvHD
As to TRM and III-IV grade aGVHD
, the incidences of patients treated with G-BM were significantly lower chance to develop aGVHD
and greater chance of survival than those treated with SS-BM [Figure 2]a and b.
of the liver develops within 2 to 10 weeks of alloHCT and occurs in approximately 40-60% of HLA-identical transplants [2,3,6,50,51].
ONTAK was well tolerated and demonstrated activity in treating steroid resistant aGVHD
without an increase in relapse risk or unexpected infections.
To support filing of a biologic license application (BLA) to the FDA for regulatory approval, Mesoblast is conducting a 60-patient, open label Phase 3 trial using MSC -100-IVas front-line therapy in children with steroidrefractory aGvHD
This large EAP data set continues to provide support for the benefit of MSC 100-IV for the treatment of aGVHD