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AROAutosomal Recessive Osteopetrosis
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AROAdvanced Reactor Operations
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AROAuxiliary Retail Outlet
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References in periodicals archive ?
CYP1A, 2B, 3A)-mediated metabolism in mammals and other non-targeted organisms, and these chemicals are also known as aromatase inhibitors (AIs) which block cytochrome P450 aromatase (P450arom) activity, resulting in a decrease in estrogen production (Allen et al.
MONALEESA-2 enrolled 668 postmenopausal women with HR+/HER2- advanced or metastatic breast cancer who received no prior systemic therapy for their advanced breast cancer and showed that Kisqali plus letrozole, an aromatase inhibitor, reduced the risk of progression or death by 43% over letrozole alone (median PFS=25.
The resulting aromatase activity inhibition was estimated using the Hill's dose-response model parameters provided by ToxCast[TM] (Dix et al.
In sheep, the Cyp19 gene that codes the aromatase enzyme is located in chromosome 7 (Payen et al.
It found that aromatase inhibitors saved more lives than tamoxifen.
Key clinical point: Aromatase inhibitors don't help shorter boys grow taller.
Key clinical point: Breast cancer patients on adjuvant aromatase inhibitor therapy have previously unappreciated dental health issues.
However, there was some estradiol level left in the circulation even after aromatase inhibition which could be due to two reasons; firstly the blood sample was pooled where specimens of both the genetic sexes might have been present and alternately some estradiol level may be needed for maintenance of testicular activity since Cyp19 gene is highly conserved in fish [12].
These mutations activate the estrogen receptor when there is no estrogen--as is the case when a patient takes an aromatase inhibitor," says lead study author Dan Robinson, PhD.
Aromatase is the name of the enzyme present in female and male bodies that transforms testosterone into estrogen in one step.
Growing evidence demonstrates that aromatase (eypl9a 1 a) mRNA is expressed before sex differentiation both in fish and reptiles (Ramsey et al.
Aromatase inhibitors are drugs that block the production of estrogen.