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In Japan, the two companies are currently conducting phase II clinical studies of NM-702 for the treatment of intermittent claudication caused by arteriosclerosis obliterans and lumber spinal canal stenosis as well as bronchial asthma. Pathological studies have demonstrated that 70% of BFD patients have histologic lesions compatible with the changes of arteriosclerosis obliterans and 30% with the changes of thromboangiitis obliterans (Yeh and How 1963). Pathologically, BFD is compatible with thromboangiitis obliterans and arteriosclerosis obliterans (12,13). |
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