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Care should also be taken to avoid benzodiazepine overdose, which can result in respiratory depression, especially in elderly individuals. Furthermore, no benzodiazepine has been studied in an extended, rigorous trial, says Krystal. Additional inclusion criteria for both groups were: age of 20 to 60 years, no spine surgery in the previous 6 months, no involvement in a disability insurance claim, free of concurrent painful conditions, and reported no use of opioid analgesics, benzodiazepine, antidepressant, or anticonvulsant medication within the 3 weeks prior to testing. |
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