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BM-bone marrow involvement
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In our study, majority of patients with CNS relapse had advance stage disease (III/IV), extranodal disease, high LDH and bone marrow involvement, which are considered as high risk population.
Data describing the frequency of bone marrow involvement and various patterns of infiltration in Non-Hodgkin lymphoma patients in local population is scarce.
Elevated LDH (>5x normal) and bone marrow involvement also serve as poor prognostic factors and were all present in this case.
Bone marrow involvement was identified in this swan, as it was in 2 other reported cases, by antemortem testing.
Flow-cytometric analysis is the best tool for immunophenotyping of hematolymphoid malignancies and is valuable in establishing the diagnosis of HSTL, especially in cases with extensive bone marrow involvement and circulating neoplastic cells.
Development and validation of a clinical prediction rule for bone marrow involvement in patients with Hodgkin lymphoma.
1) Anemia, (2) leukopenia,3 and both anemia and leukopenia occurring simultaneously, (4) secondary to bone marrow involvement in LL, have been demonstrated.
Haemopoietic involvement occurs most frequently in young children with diffuse disease and is defined as cytopenias, splenomegaly or bone marrow involvement.
In conclusion, myeloid leukemias might present with granulocytic sarcomas, particularly in skin without bone marrow involvement.
Bone marrow involvement is seen in 5% of patients with HD presenting with anaemia, leucopenia and thrombocytopenia.
Bone marrow involvement may demonstrate the following characterstics: increase in granulocytes, monocytes, and eosinophils and there may be areas of fibrosis along with the abnormal infiltration of lymphocytes and macrophages without the presence of Hodgkin-Reed cells.
17) Cytogenetic analysis of the tumor and bone marrow may aid in the confirmation of a presumptive diagnosis whenimmunohistochemical studies produce conflicting results or when bone marrow involvement in leukemia lags behind peripheral manifestations.
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