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c-IAP1Cellular Inhibitor of Apoptosis Protein 1
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AT-406 is an orally-active, small molecule drug designed to promote programmed cell death (apoptosis) in tumor cells by blocking the activity of at least three "inhibitors of apoptosis proteins" or IAPs (including XIAP, c-IAP1, and c-IAP2) to create conditions in which apoptosis can proceed.
Additional genes implicated include the genes that code for mammalian inhibitor of apoptosis (IAP), where both c-IAP1 and c-IAP2 have been shown to be up-regulated by NF-[kappa]B.
NF-[kappa]B antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and cIAP2 to suppress caspase-8 activation.