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cFLIP |
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p53 upregulates cFLIP, inhibits transcription of NF-[kappa]B-regulated genes and induces caspase-8-independent cell death in DLD-1 cells. To regulate the amplitude of the apoptotic signal, p53 induces the inhibitor genes TRUNDD/TRAIL-R4, TRID/TRAIL-R3, and cFLIP. The presentation, titled "Antisense Inhibition of cFLIP Promotes Transplant Acceptance by Sensitizing Responding T Cells to Undergo Activation Induced Apoptosis," was presented by AVI senior scientist Dan Mourich, Ph. |
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