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CRAT
(redirected from carnitine acetyltransferase)

   Also found in: Dictionary/thesaurus, Medical, Encyclopedia, Wikipedia 0.01 sec.
AcronymDefinition
CRATCharitable Remainder Annuity Trust
CRATCertified Rational Addictions Therapist (psychology)
CRATCenter for Rehabilitation and Abolition of Torture (Cameroon)
CRATCivil Rights Action Team (USDA)
CRATCarnitine Acetyltransferase
CRATCyber Regulations Appellate Tribunal (India)
CRATCommission Régionale d'Aménagement du Territoire (French: Regional Commission for Regional Development; Belgium)


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As explained, the acetyl-CoA is attached to L-carnitine by means of the enzyme carnitine acetyltransferase I.
In feeding studies in old rats, these mitochondrial metabolites and antioxidants improve the age-associated decline of ambulatory activity and memory, partially restore mitochondrial structure and function, inhibit the age-associated increase of oxidative damage to lipids, proteins, and nucleic acids, elevate the levels of antioxidants, and restore the activity and substrate binding affinity of a key mitochondrial enzyme, carnitine acetyltransferase.
Materials and methods Chemicals and reagents Berberine, ethylenediaminetetraacetic acid (EDTA), 2-aminofluorene (AF), N-acetyl-2-aminofluorene (AAF), dithiothreitol (DTT), Tris, acetylcarnitine, leupeptin, bovine serum albumin (BSA), phenylmethylsulfonylfluoride (PMSF), dimethyl sulfoxide (DMSO), acetyl-coen-zyme A (Acetyl-CoA) and carnitine acetyltransferase were obtained from Sigma Chemical Co.
 
 
 
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