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CASPASE |
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In tests with primary T cells or Jurkat T leukemia cells, the extended presence of YopH led to apoptosis through a mitochondria-dependent pathway, as indicated by mitochondrial breakdown, caspase activation, DNA fragmentation, and annexin V binding. Idun Pharmaceuticals' IDN-6556 is a liver-targeting caspase inhibitor that prevents apoptosis (cell death). Now, a team of researchers has found compounds that inhibit a specific caspase inhibitor, thereby triggering the death of various tumor cells growing in laboratory dishes or in mice. |
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