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cccDNA

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AcronymDefinition
cccDNACovalently Closed Circular Deoxyribonucleic Acid


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During transcription, cccDNA is replenished by returning to the hepatocyte nucleus.
Attainment of HBeAg or HBsAg seroconversion with therapy is rarely seen, especially in HIV-infected individuals, given the stability of the cccDNA reservoir within infected hepatocytes.
Activity of Adefovir Dipivoxil Against cccDNA Preliminary results evaluating the effect of adefovir dipivoxil treatment on cccDNA (covalently closed circular DNA) in chronic hepatitis B patients with HBeAg+ disease enrolled in Study 437 (substudy, n=20) will be presented by Fabien Zoulim, MD, Inserm Unit 271, Lyon, France (#638).
 
 
 
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