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The patients will be randomized on a 2:1 basis: approximately 250 patients will be treated with Allovectin-7(r) and approximately 125 will be treated with their physician's choice of either of two chemotherapy agents, dacarbazine or temozolomide. Dacarbazine, the standard chemotherapeutic drug for melanoma for decades, has been ineffective when used alone. Effective agents include cyclophosphamide, etoposide, vincristine, ifosfamide, doxorubicin (Adriamycin), dactinomycin (Actinomycin D), dacarbazine and investigational agent. |
dacarbazine |
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