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At first, relapsed patients were treated with a combination of sodium stibogluconate and allopurinol, which was unsuccessful in contrast with its reported success in Kenya, or with amphotericin deoxycholate (8). In a Phase III randomized, double-blind study, patients with a proven diagnosis of invasive candidiasis received daily doses of CANCIDAS (50 mg/day following a 70-mg loading dose on Day 1) or amphotericin B deoxycholate (0. The virus is stable when treated with nonionic detergents (such as Tween 20) or with organic solvents (such as Freon 113 or its ozone-friendly substitute Vertrel XF), but viral infectivity is abolished by treatment with sodium deoxycholate or sodium dodecyl sulfate (16,17). |
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