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Related to ganciclovir: Valganciclovir
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References in periodicals archive ?
Owing to its cost-effectiveness, intravitreal ganciclovir injection is the current standard treatment in the SA public sector for active CMV retinitis infection, [23] even though systemic ganciclovir or valganciclovir therapy is standard of care in other countries as these drugs assist in the prevention of systemic dissemination and improving survival.
While topical ganciclovir is approved for use in acute herpetic keratitis, its efficacy has also been demonstrated against cytomegalovirus and some strains of adenovirus, while systemic administration of ganciclovir is effective against HIV (16) Although there are no previous studies showing that topical ganciclovir is effective against MC, we initially administered it to both of our patients considering its broad-spectrum antiviral activity, but no improvement was achieved.
Valganciclovir is an orally bioavailable prodrug metabolized rapidly to ganciclovir in intestinal tissues and the liver (Woo & Robinson, 2016).
Universal prophylaxis with intravenous ganciclovir (5mg/kg) was implemented according to previous institutional protocol: P.
Cytomegalovirus pp65 antigenemia-guided early treatment with ganciclovir versus ganciclovir at engraftment after allogeneic marrow transplantation: a randomized double-blind study.
The infection did not respond to ganciclovir or foscarnet, and CMV viral load was rising.
A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells.
Remission of HHV-8 and HIV associated multicentric Castleman disease with ganciclovir treatment.
Treatment is with intravitreal ganciclovir injections and oral acyclovir, but once retinal detachment occurs, surgery is needed.
Prevention of primary cytomegalovirus disease in organ transplant recipients with oral ganciclovir or oral acyclovir prophylaxis.
CMV has been called the 'neglected disease of the AIDS pandemic', in part because of limited access to treatment, especially in the developing world, where localised intra-ocular ganciclovir implants and systemic oral valganciclovir are unavailable or too costly.