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Specifically, the partners have succeeded in inducing most of neural cell species including neurons and glia cells from mouse embryonic stem cells. In aggregating cultures of primary neurons and glia, CPF inhibits the emergence of the cholinergic phenotype much more than does parathion, despite the fact that the latter is more systemically toxic and more potent toward cholinesterase inhibition, and physostigmine is less effective (Monnet-Tschudi et al. Instead, they're part of an ensemble performance involving other types of brain cells collectively known as glia (SN: 4/7/01, p. |
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