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References in periodicals archive ?
Within the large population of patients with previously diagnosed chronic kidney disease (CKD) that were studied, sex, race, and age were the most important variables that influenced serum creatinine correlations with GFR measured by iothalamate clearance.
They found that none of the measures of GFR--including iothalamate clearance--associated strongly with CKD complications and that the relative strengths of association varied with different outcomes, raising the philosophical question of whether measured GFR is truly the appropriate gold standard.
Assessment of iothalamate plasma clearance: duration of study affects quality of GFR.
Perrone RD, Steinman TI, Beck GJ, Skibinski CI, Royal HD, Lawlor M, Hunsicker LG Utility of radioisotopic filtration markers in chronic renal insufficiency: simultaneous comparison of 125I iothalamate, 169Yb-DTPA, 99mTc-DTPA, and inulin The Modification of Diet in Renal Disease Study.
Barbour GL, Crumb CK, Boyd CM, Reeves RD, Rastogi SP, Patterson RM Comparison of inulin, iothalamate, and 99mTc-DTPA for measurement of glomerular filtration rate.
To minimize interference with iothalamate quantification, the previously reported CE-UV method used in our laboratory (7,8) has since been modified to run in reverse polarity.
Ethylenediamine dihydrochloride, phenyl phosphate, cetyldimethylethyl ammonium bromide, sodium hydroxide, and formic acid were purchased from Sigma Aldrich; hydrochloric acid, phosphoric acid, acetonitrile, methanol (HPLC grade), and water (HPLC grade) from Fisher Scientific; and Conray[R] iothalamate meglumine injection USP 60% from Malinkrodt Inc.
The very high correlation found between 1/cystatin C and iothalamate clearance in this study suggests that at least in patients with CKD, kidney dysfunction is the most likely explanation for the prognostic value of cystatin C.
The currently recommended estimating equation was developed from the Modification of Diet in Renal Disease (MDRD) Study (15) and is based on GFR values measured by iothalamate clearance in 1628 adults and subsequently validated in another 1775 adults in the African American Study of Kidney Disease (AASK) (16).
We recently found that capillary electrophoresis (CE) is an efficient, inexpensive, and reliable method for measurement of the nonradiolabeled iothalamate in urine and plasma samples for the assessment of glomerular filtration rate (8,9).
Measurement of the renal clearance of infused tracers such as inulin, iothalamate, or iohexol can provide accurate measurements of GFR, but they are too costly and cumbersome for routine clinical use.
2] by iothalamate clearance, whereas SCr became abnormal at 75 mL x [min.