Conclusion: Mutation pattern of rpoB gene that confers rifampicin resistance is different to a little extent from other national and international studies while pattern is same for katG gene that confers isoniazid
Conclusion: One novel mutation at codon 303 in catalase-peroxidase gene was found in the study, and it could contribute to isoniazid
(hidrazid acid 4-piridinkarboksilat, INH) is a mainstay chemical agent used for the treatment of TB, since first introduced in 1951 to the present.
Therefore, all 50 latent TB patients were offered three treatment options: 1) 9 months of daily isoniazid
, self-monitored, with monthly visits to the health department; 2) 4 months of daily rifampin, self-monitored, with visits to the health department every 2 weeks for the first month, and once per month thereafter; or 3) 12 weekly doses of rifapentine and isoniazid
administered under DOT.
tuberculosis with available TB drug susceptibility tests results for at least isoniazid
tuberculosis for susceptibility against isoniazid
, rifampicin, ethambutol, and streptomycin.
Guidelines for Intensified Tuberculosis Case- finding and Isoniazid
Preventive Therapy for People Living with HIV in Resource-Constrained Settings.
Isolate 1 Isolate 2 Isolate 3 detected detected detected resistance resistance resistance Phenotypic drug Rifampicin; Rifampicin; Rifampicin; susceptibility Isoniazid Isoniazid
testing (DST) (a) Pyrazinamide Ofloxacin; (b) Pyrazinamide Ethambutol (c) Genotype MTBDRplus NA Rifampicin Rifampicin (R; H) Isoniazid Isoniazid
Genotype MTBDRsl NA Ethambutol Ethambutol FQ (E; FQ; SLID) WGS NA Available (see Available (see Table 2) Table 2) NA, not available; R, rifampicin; H, isoniazid
; E, ethambutol; FQ, fluoroquinolones; SLID, second line injectable drugs.
As a result, of the 42 strains resistant to isoniazid
, 5 strains had mutations in inhA-15.
of patients who were resistant 06 to Rifampicin & Isoniazid
1 Standard treatment of tube- rculosis consists of a six to nine months course of anti- biotics named isoniazid
(INH) pyrazinamide (PZA) rifampicin (RIF) and ethambutol or streptomycin.
The researchers added isoniazid
and a 'reducing agent' known as cysteine to the TB in a test tube, expecting the bacteria to develop drug resistance.