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3TCLamivudine (GlaxoSmithKline)
3TCDideoxythiacytidine (antiviral drug)
References in periodicals archive ?
India-based Aurobindo Pharma (NSE: AUROPHARMA) has been granted tentative approval by the US Food and Drug Administration (FDA) for dolutegravir, lamivudine and tenofovir disoproxil fumarate tablets, the company said on Monday.
However, given the recent testimonials regarding lamivudine effectiveness in treating EBOV-infected patients in Africa, we conducted additional studies to determine whether our previous assertion that lamivudine lacked any direct antiviral activity was correct.
Lamivudine was the first nucleoside analogue approved for the treatment of CHB, showing to be beneficial by reducing HBV DNA levels, normalizing ALT and improving histological liver in short-term treatments.
In this issue, Kumar et al (2) performed a randomized pilot study to compare lamivudine and adefovir in terms of the HBV kinetics.
A second, entirely separate source of selection pressure promoting the creation of VEMs stems from the fact that lamivudine frequently leads to mutations in the gene for reverse transcriptase, which happens to overlap the surface antigen gene.
Lamivudine is associated with the development of the highest rate of resistance.
The newer drug achieved better therapeutic and histologic responses than lamivudine did in some subsets of patients, and had greater antiviral efficacy overall, said Dr.
Telbivudine, a recently approved HBV-polymerase inhibitor, has shown superior antiviral efficacy compared to lamivudine in HBe-antigen-positive and -negative patients.
The most common adverse events for telbivudine and lamivudine, regardless of attributability, were upper respiratory infection, headache, fatigue and nasopharyngitis.
That lesson was brought home by the experience with lamivudine, a nucleoside analog that was the first oral antiviral agent approved for chronic hepatitis B.
Both abacavir and tenofovir DF select for the K65R mutation, which reduces susceptibility to both drugs, as well as to lamivudine [3TC].
En el presente trabajo son estudiados los posibles efectos de la lamivudine cuando es administrada durante toda la prenez de la rata albina.