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The NSAIDs that are currently available seem to have little or no effect on lipoxygenase, which transforms arachidonic acid to leukotrienes. If the THF-diols or LTX-diols modulate luteinizing-hormone-releasing hormone release via pathways related to NO synthase, phospholipase A (PLA), cyclooxygenase (COX), or lipoxygenase (LOX), the compounds may directly or indirectly control breast or prostate cancer growth and proliferation via modulation of gonadotropin release and/or ovarian or testicular steroidogenesis. Cyclooxygenase and lipoxygenase metabolite generation in nasal polyps. |
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