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The liver enzyme aspartate aminotransferase, an indicator of fatty liver disease, was detected in the blood samples of 42% of obese males tested and just 3% of males of 'normal weight'. Limited treatment options, a low number of donor organs, the high price of transplants and follow up costs, a growing base of hepatitis, alcohol abuse, drug overdoses, and other factors that result in liver disease all clearly indicate a strong need for an artificial liver device. This program announcement addresses several areas considered to be high priority for liver disease research as delineated in the recently published Trans-NIH Action Plan for Liver Disease Research (http://liverplan. |
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