Results of our study show a similar increase in scatter of observations at higher mGFR
4] Nonstandard abbreviations: GFR, glomerular filtration rate; mGFR
, measured GFR; eGFR, estimated GFR; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; WG-SCC, Working Group for the Standardization of Cystatin C; CAPA, Caucasian and Asian Pediatric and Adult subjects.
The MDRD study demonstrated that the eGFR correlated well with mGFR determined by urinary clearance of 125I-iothalamate in the CKD patients in the lower eGFR <60 ml/min/1.
73 m2 group there was an overestimation of mGFR by 17.
When the CKD-EPI equation was applied to the South African CHB CKD dataset, all levels of mGFR were found to be overestimated (to a lesser degree at ranges >60 ml/min/1.
There is little convincing evidence that the CKD-EPI equation in its present form can be used as an improved method of estimating mGFR in African populations with GFR >60 ml/min/1.
Creatinine clearance (CrCl) overestimates the mGFR.
The difference between eGFR and mGFR at different levels of mGFR by use of this final CAPA equation and the CKD-EPI equation on the entire data set of Swedish and Japanese adult cohorts as well as among children is presented together with limits for P30 accuracy in Fig.
The CKD-EPI equation is based on finding a mathematical-statistical connection between mGFR and cystatin C, sex, and age of the individuals of the population studied without attempting to express the equation so that it might be given a biological interpretation.
In each of these groups, the median difference between eGFR and mGFR (bias), percentage bias, IQR of the difference between eGFR and mGFRs, and root mean squared error were calculated.
212 as suggested for African Americans overestimated mGFR in black South Africans.
51]Cr-EDTA, chromium-51-EDTA; eGFR, estimated GFR; S-Cr, serum creatinine; 4-v MDRD, 4-variable Modification of Diet in Renal Disease; CG, Cockcroft-Gault; IDMS, isotope dilution mass spectrometry; CrCl, creatinine clearance; BSA, body surface area; mGFR, measured GFR; IQR, interquartile range.