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These patents are based on a newly identified mRNA element which significantly improves expression of the encoded therapeutic protein and represent an essential part of CureVac's technology platform, broadening and strengthening the company's leading intellectual property (IP) position in the mRNA field.
It profiles existing vaccines based on mRNA and therapeutics.
Results: SIRT3 mRNA expression was higher in the RA group than in the healthy control group (4.
The cDNA templates were then diluted 1:4 with nuclease-free water and amplified by polymerase chain reaction (PCR) using Taq polymerase (Takara Bio, Shiga, Japan), and specific primers based on porcine ABCC1, ABCC9, SLCO4C1, and SLCO5A1 mRNA sequences.
Dynamic mRNA Transport and Local Translation in Radial Glial Progenitors of the Developing Brain," Current Biology, 2016; DOI: 10.
Another surprising observation occurred when the researchers looked at mRNA translation in cancer cells.
Human papillomavirus oncogenic mRNA testing for cervical cancer screening; baseline and longitudinal results from the CLEAR study.
Relative changes in mRNA expression from Pre values of each control are presented in Figure 5.
The C1 mRNA Seq HT IFC can capture up to 800 cells at a time, and employs a new protocol to facilitate two runs-or 1,600 cells-a day.
Stage 2: Identification of mRNA strands formed in vitro by CPV transcriptase.
Several polymorphisms of Nurr1 gene including −291Tdel and −245T-->G have been reported to result in a marked decrease of Nurr1 mRNA levels in transfected cell lines and lymphocytes of affected individuals.
During early stages of HR bZIP60 mRNA splicing is observed as well as transcriptional up-regulation of some ER marker genes, suggesting that UPR and in particular IRE1 are involved in pro-death signaling.
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- mRNA binding site
- mRNA-decapping enzyme 2