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Related to methemoglobin: methemoglobin test, Methemoglobin reductase
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In a normal physiologic state, there is roughly 1% methemoglobin in the RBCs.
Confirmation of the diagnosis requires CO-oximetry testing, which utilizes multiple wavelengths of light to detect serum methemoglobin levels.
In 2005, Masimo introduced rainbow SET Pulse CO-Oximetry technology, allowing noninvasive and continuous monitoring of blood constituents that previously required invasive procedures, including total hemoglobin (SpHb), oxygen content (SpOC (TM)), carboxyhemoglobin (SpCO), methemoglobin (SpMet), and Pleth Variability Index (PVI), in addition to SpO2, pulse rate, and perfusion index (PI).
If methemoglobin level is above 30%, 1% methylene blue can be administered intravenously at a dose of 1-2 mg/kg.
Cooximetry uses four wavelengths of light to measure the absorptive characteristics of oxy- and deoxyhemoglobin, methemoglobin, and carboxyhemoglobin species.
This new pulse oximeter, at this point, is the only device which can readily measure carboxyhemoglobin, methemoglobin, and hemoglobin.
A significantly higher mean value of methemoglobin was found when nitrate concentration in well water exceeded 100 mg/L (Table 4).
Reddy measured carboxyhemoglobin and methemoglobin levels using the Rad-57 Pulse CO-Oximeter (Masimo Corp.
It has been suggested that the placental membrane is effective in separating blood circulation between mother and fetus from the fourth month of pregnancy, thus preventing methemoglobin molecules from crossing (L'hirondel and L'hirondel 2002).
The presence of methemoglobin or a similar dysfunctional hemoglobin species may render simple clinical assumptions invalid.
Methemoglobin, with its shortT1 relaxation time on T1-weighted imaging, is easily identified in the membranous labyrinth because of the distinct contrast between it and the surrounding bony signal void of the otic capsule.