were identified according to the following criteria: micronucleus is distinctly separated from the parental nuclei; size of micronucleus is smaller than one-third the size of the main nuclei; and if there were more than two micronuclei
present in a cell, the micronuclei
were not counted.
A higher count of micronuclei
is thus a barometer of the risk.
Evaluation of chromosome aberrations, sister chromatid exchange and micronuclei
in patients with type-1 diabetes mellitus.
are small nuclei like particles seen apart from the nucleus in an irradiated cell.
Genotoxicity was determined by counting the number of micronucleated meristametic cells from at least 2000 meristametic per preparation evaluated by the number of micronuclei
in 2000 interphase nuclei per bulb, the micronucleus frequency (expressed as percent micronucleated cells) .
Pre-treatment samples showed micronuclei
to be in the range of 23 to 46 per 1000 cells (mean=30.
Induction of micronuclei
in murine lymphocytes by morphine.
However, cypermethrin administered intraperitoneally at doses [greater than or equal to] 30 mg/kg significantly increased the incidence of chromosomal aberrations and micronuclei
in bone marrow and the percent of sperm with head abnormalities .
These advancements are designed to accelerate the throughput of High-Content Screening (HCS) and expand toxicity applications to include micronuclei
Rochester, NY) has patented a method for the enumeration of mammalian cell micronuclei
, while distinguishing micronuclei
from the chromatin of dead and dying cells.
In 1991, Westmoreland and Gatehouse revealed the clastogenic properties of sudan I in an vivo rodent micronuclei
test;, more recent studies have suggested possible carcinogenicity in humans through the formation of DNA adducts (dose range 0.
Exploring the clastogenic effects of air pollutants in São Paulo (Brazil) using the Tradescantia micronuclei