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As "Dying to Live" concludes its final chapter, "The Anteroom," Midgley explains that he is in the process of experiencing motor neuron disease, a deterioration of the nerve fibers that help convey signals from the spinal cord and brain to the rest of the body. Stanley Sadie, 74, editor of Grove music dictionary, died March 21, 2005, at his home in Cossington, England, of motor neuron disease, his family said. The genetic defects identified in FALS have lead to the development of some useful animal models of the disease, but more models are needed to expand research on the abnormal biology of the affected motor neuron and nonneuronal cells, on nervous system response to endogenous and environmental toxins and toxicants, and on identification of metabolic, endocrine, and immunological abnormalities. |
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