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References in periodicals archive ?
While studying the stem cells as they developed into motor neurons in fruit fly larvae, they noticed that in the midst of this process, some of these stem cells took a detour.
Denervation activity in the EMG of patients with upper motor neuron lesions: Time course, local distribution and pathogenetic aspects.
Subcommittee on Motor Neuron Diseases/Amyotrophic Lateral Sclerosis of the World Ferderation of Neurology Research Group on Neuromuscular Diseases and the El Escorial Clinical limits of amyotrophic Lateral sclerosis workshop contributors.
Dr Ivo Lieberam of the MRC Centre for Developmental Neurobiology, King's College London said that they custom-tailored embryonic stem cells so that motor neurons derived from them can function as part of the muscle pacemaker device, asserting that first they equipped the cells with a molecular light sensor and that enabled them to control motor neurons with blue light flashes.
Familial, on the other hand, is linked to a mutation of the enzyme called superoxide dismutase 1 (SOD1) and with an over-stimulation of motor neurons by the neurotransmitter glutamate.
It became clear that these proteins weren't randomly expressed, but were expressed in highly precise patterns that cor-responded to ana-tomically defined motor neuron pools," says Jessell.
Two years later, he exhibited a complete left lower motor neuron facial nerve palsy.
The term motor neuron disease was introduced by Brain (1962) in recognition of the relationship between progressive muscular atrophy, amyotrophic lateral sclerosis, and progressive bulbar palsy, as shown by the differing patterns of involvement of upper and lower motor neurons and muscle wasting in these syndromes (Swash, 2000; Swash & Desai, 2000).
For example, the chapter on the initial rehabilitation medicine consultation includes a statement of the purpose of the chapter, elements of a consultation, bladder management, bowel management, pressure ulcers, contractures, autonomic dysfunction, upper motor neuron syndrome and spasticity, DVT prophylaxis, pulmonary issues, psychological adaptation, pain, comorbid conditions, disposition and discharge planning, long-term issues, and ends with a checklist of important report elements.
ALS is also called a motor neuron disease, which is a general term that refers to a group of disorders that also includes the spinal muscular atrophies, genetic diseases of lower motor neurons.
The effect of spinal cord injury on sexual response is generally discussed based upon the degree of completeness or incompleteness of the patient's injury and whether the neurologic damage affecting the individual's sacral spinal segments is an upper or lower motor neuron injury.
Conclusions: Increased repeater F waves reflect increased excitability of motor neuron pool and indicate upper motor neuron dysfunction in ALS.